A graduate of EFAP, Priscille Garcin began her career with the Publicis group, before joining the office of the Minister of Health and then that of the Minister of Culture as press advisor. After serving as communications delegate for the Centre National du Cinéma, she joined France Télévisions as group communications director.

In 2010, she joined the SNCF Group as Director of Media Relations and Crisis Communications, before moving to SNCF Réseau as Director of Communications, External Relations and Consultation, and member of the Executive Committee.

In 2017, she was appointed Director of Information and Communication Strategy for the SNCF Group. 
In 2020, she joined SNCF Gares & Connexions as Director of Paris Gare de Lyon and Paris Bercy Bourgogne Pays d'Auvergne stations. In March 2023, she was appointed Advisor to the Director General, responsible for coordinating major sporting events.

In November 2023, Priscille Garcin became Director of Communications and Major Sports Events. In this role, she is responsible for managing external communication, influence, media relations, the brand and internal commitment, and she coordinates the 2024 Olympic and Paralympic Games programme within SNCF Gares & Connexions.